Diagnosis and early detection of CNS-SLE in MRL/lpr mice using peptide microarrays.

ABSTRACT:

Background

An accurate method that can diagnose and predict lupus and its neuropsychiatric manifestations is essential since currently there are no reliable methods. Autoantibodies to a varied panel of antigens in the body are characteristic of lupus. In this study we investigated whether serum autoantibody binding patterns on random-sequence peptide microarrays (immunosignaturing) can be used for diagnosing and predicting the onset of lupus and its central nervous system (CNS) manifestations. We also tested the techniques for identifying potentially pathogenic autoantibodies in CNS-Lupus. We used the well-characterized MRL/lpr lupus animal model in two studies as a first step to develop and evaluate future studies in humans.

Results

In study one we identified possible diagn

SUBMITTER: Williams S 

PROVIDER: S-EPMC4065311 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature