Cysteine promoted C-terminal hydrazinolysis of native peptides and proteins.

ABSTRACT: Tagging the terminus: N→S acyl transfer in native peptides and proteins can be reliably intercepted with hydrazine. The method allows selective labeling and ligation, without recourse to the use of protein-splicing elements. NCL=native chemical ligation.

SUBMITTER: Adams AL 

PROVIDER: S-EPMC4065347 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature