Allogeneic cell therapy bioprocess economics and optimization: single-use cell expansion technologies.

ABSTRACT: For allogeneic cell therapies to reach their therapeutic potential, challenges related to achieving scalable and robust manufacturing processes will need to be addressed. A particular challenge is producing lot-sizes capable of meeting commercial demands of up to 10(9) cells/dose for large patient numbers due to the current limitations of expansion technologies. This article describes the application of a decisional tool to identify the most cost-effective expansion technologies for different scales of production as well as current gaps in the technology capabilities for allogeneic cell therapy manufacture. The tool integrates bioprocess economics with optimization to assess the economic competitiveness of planar and microcarrier-based cell expansion technologies. Visualization methods wer

SUBMITTER: Simaria AS 

PROVIDER: S-EPMC4065358 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature