Neuroimaging predictors of cognitive performance across a standardized neurocognitive battery.

ABSTRACT:

Objective

The advent of functional MRI (fMRI) enables the identification of brain regions recruited for specific behavioral tasks. Most fMRI studies focus on group effects in single tasks, which limits applicability where assessment of individual differences and multiple brain systems is needed.

Method

We demonstrate the feasibility of concurrently measuring fMRI activation patterns and performance on a computerized neurocognitive battery (CNB) in 212 healthy individuals at 2 sites. Cross-validated sparse regression of regional brain amplitude and extent of activation were used to predict concurrent performance on 6 neurocognitive tasks: abstraction/mental flexibility, attention, emotion processing, and verbal, face, and spatial memory.

Results

Brain activation was ta

SUBMITTER: Roalf DR 

PROVIDER: S-EPMC4065574 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature