Intermediate CGG repeat length at the FMR1 locus is not associated with hormonal indicators of ovarian age.

ABSTRACT:

Objective

Premutation and intermediate CGG repeat length at the fragile X mental retardation 1 (FMR1) locus have been associated with premature ovarian failure. We tested whether intermediate length is associated with indicators of ovarian age in a sample of fertile women. Our primary measures of ovarian age were antimüllerian hormone (AMH) and follicle-stimulating hormone (FSH) levels.

Methods

The cross-sectional sample comprised 258 women with karyotyped spontaneous abortions (140 trisomic spontaneous abortions and 118 chromosomally normal spontaneous abortions or spontaneous abortions with anomalies other than trisomy) and 325 women with recent live births (LBs). We analyzed data from the total sample and data from LBs only. We defined CGG repeat length by the length (bot

SUBMITTER: Kline JK 

PROVIDER: S-EPMC4065625 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature