Redox regulation of 14-3-3ζ controls monocyte migration.

ABSTRACT:

Objective

Metabolic stress primes monocytes for accelerated chemokine-mediated adhesion, migration, and recruitment into vascular lesions by increasing actin remodeling. The mechanism linking metabolic stress to accelerated actin turnover and enhanced monocyte migration was not known. We tested the hypothesis that in metabolically primed monocytes, the acceleration of monocyte chemoattractant protein-1-induced chemotaxis is mediated by the hyperactivation of cofilin.

Approach and results

Metabolic priming was induced by exposing human THP-1 monocytes to diabetic conditions, that is, human native low-density lipoprotein plus high glucose concentrations. In healthy monocytes, monocyte chemoattractant protein-1 induced the phosphorylation and inactivation of cofilin. This respo

SUBMITTER: Kim HS 

PROVIDER: S-EPMC4065841 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature