Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia.

ABSTRACT:

Background

Schizophrenia, a severe psychiatric disorder, has a lifetime prevalence of 1%. The exact mechanisms underlying this disorder remain unknown, though theories abound. Recent studies suggest that particular cell types and biological processes in the schizophrenic cortex have a pseudo-immature status in which the molecular properties partially resemble those in the normal immature brain. However, genome-wide gene expression patterns in the brains of patients with schizophrenia and those of normal infants have not been directly compared. Here, we show that the gene expression patterns in the schizophrenic prefrontal cortex (PFC) resemble those in the juvenile PFC.

Results

We conducted a gene expression meta-analysis in which, using microarray data derived from differen

SUBMITTER: Hagihara H 

PROVIDER: S-EPMC4066280 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature