Concordant release of glycolysis proteins into the plasma preceding a diagnosis of ER+ breast cancer.

ABSTRACT: Although the identification of peripheral blood biomarkers would enhance early detection strategies for breast cancer, the discovery of protein markers has been challenging. In this study, we sought to identify coordinated changes in plasma proteins associated with breast cancer based on large-scale quantitative mass spectrometry. We analyzed plasma samples collected up to 74 weeks before diagnosis from 420 estrogen receptor (ER)(+) cases and matched controls enrolled in the Women's Health Initiative cohort. A gene set enrichment analysis was applied to 467 quantified proteins, linking their corresponding genes to particular biologic pathways. On the basis of differences in the concentration of individual proteins, glycolysis pathway proteins exhibited a statistically significant differenc

SUBMITTER: Amon LM 

PROVIDER: S-EPMC4066614 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature