ESX1-dependent fractalkine mediates chemotaxis and Mycobacterium tuberculosis infection in humans.

ABSTRACT: Mycobacterium tuberculosis-induced cellular aggregation is essential for granuloma formation and may assist establishment and early spread of M. tuberculosis infection. The M. tuberculosis ESX1 mutant, which has a non-functional type VII secretion system, induced significantly less production of the host macrophage-derived chemokine fractalkine (CX3CL1). Upon infection of human macrophages ESX1-dependent fractalkine production mediated selective recruitment of CD11b+ monocytic cells and increased infection of neighbouring cells consistent with early local spread of infection. Fractalkine levels were raised in vivo at tuberculous disease sites in humans and were significantly associated with increased CD11b+ monocytic cellular recruitment and extent of granulomatous disease. These findings

SUBMITTER: Hingley-Wilson SM 

PROVIDER: S-EPMC4066952 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature