Aggregate risk score based on markers of inflammation, cell stress, and coagulation is an independent predictor of adverse cardiovascular outcomes.

ABSTRACT:

Objectives

This study sought to determine an aggregate, pathway-specific risk score for enhanced prediction of death and myocardial infarction (MI).

Background

Activation of inflammatory, coagulation, and cellular stress pathways contribute to atherosclerotic plaque rupture. We hypothesized that an aggregate risk score comprised of biomarkers involved in these different pathways-high-sensitivity C-reactive protein (CRP), fibrin degradation products (FDP), and heat shock protein 70 (HSP70) levels-would be a powerful predictor of death and MI.

Methods

Serum levels of CRP, FDP, and HSP70 were measured in 3,415 consecutive patients with suspected or confirmed coronary artery disease (CAD) undergoing cardiac catheterization. Survival analyses were performed with models adj

SUBMITTER: Eapen DJ 

PROVIDER: S-EPMC4066955 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature