Brain serotonin 1A receptor binding as a predictor of treatment outcome in major depressive disorder.

ABSTRACT:

Background

We previously reported higher serotonin 1A receptor (5-HT1A) binding in subjects with major depressive disorder (MDD) during a major depressive episode using positron emission tomography imaging with [(11)C]WAY-100635. 5-HT1A receptor binding is also associated with treatment outcome after nonstandardized antidepressant treatment. We examined whether pretreatment 5-HT1A binding is associated with treatment outcome following standardized escitalopram treatment in MDD. We also compared 5-HT1A binding between all MDD subjects in this cohort and a sample of healthy control subjects.

Methods

Twenty-four MDD subjects in a current major depressive episode and 51 previously studied healthy control subjects underwent positron emission tomography scanning with [(11)C]WAY-10

SUBMITTER: Miller JM 

PROVIDER: S-EPMC4066966 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature