Association of CYP1B1 L432V polymorphism with urinary cancer susceptibility: a meta-analysis.

ABSTRACT:

Background

The Cytochrome P450 1B1 (CYP1B1) is a key P450 enzyme involved in the metabolism of exogenous and endogenous substrates. Previous studies have reported the existence of CYP1B1 L432V missense polymorphism in prostate, bladder and renal cancers. However, the effects of this polymorphism on the risk of these cancers remain conflicting. Therefore, we performed a meta-analysis to assess the association between L432V polymorphism and the susceptibility of urinary cancers.

Methods

We searched the PubMed database without limits on language for studies exploring the relationship of CYP1B1 L432V polymorphism and urinary cancers. Article search was supplemented by screening the references of retrieved studies manually. Odds ratios (OR) and 95% confidence intervals (95% CI) w

SUBMITTER: Jiang W 

PROVIDER: S-EPMC4067118 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature