Small molecules, big roles -- the chemical manipulation of stem cell fate and somatic cell reprogramming.

ABSTRACT: Despite the great potential of stem cells for basic research and clinical applications, obstacles - such as their scarce availability and difficulty in controlling their fate - need to be addressed to fully realize their potential. Recent achievements of cellular reprogramming have enabled the generation of induced pluripotent stem cells (iPSCs) or other lineage-committed cells from more accessible and abundant somatic cell types by defined genetic factors. However, serious concerns remain about the efficiency and safety of current genetic approaches to cell reprogramming and traditional culture systems that are used for stem cell maintenance. As a complementary approach, small molecules that target specific signaling pathways, epigenetic processes and other cellular processes offer powerf

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC4067267 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature