A randomized trial of a home system to reduce nocturnal hypoglycemia in type 1 diabetes.

ABSTRACT:

Objective

Overnight hypoglycemia occurs frequently in individuals with type 1 diabetes and can result in loss of consciousness, seizure, or even death. We conducted an in-home randomized trial to determine whether nocturnal hypoglycemia could be safely reduced by temporarily suspending pump insulin delivery when hypoglycemia was predicted by an algorithm based on continuous glucose monitoring (CGM) glucose levels.

Research design and methods

Following an initial run-in phase, a 42-night trial was conducted in 45 individuals aged 15-45 years with type 1 diabetes in which each night was assigned randomly to either having the predictive low-glucose suspend system active (intervention night) or inactive (control night). The primary outcome was the proportion of nights in which ≥

SUBMITTER: Maahs DM 

PROVIDER: S-EPMC4067393 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature