Fractalkine (CX3CL1), GM-CSF and VEGF-a levels are reduced by statins in adult patients.

ABSTRACT:

Background

Fractalkine (CX3CL1) promotes migration and adhesion of lymphocytes and monocytes to inflamed tissues. Prior studies show a role for CX3CL1 in atherosclerosis. The relationship between inflammatory cytokines, cholesterol, and CX3CL1 levels in human subjects without known coronary artery disease is not well characterized. The goal of our study was to assess baseline CX3CL1 levels, and after modulation of cholesterol levels by statins to determine if CX3CL1 is linked to cholesterol levels or inflammatory stimuli.

Methods

We performed a blinded, randomized hypothesis generating study in human subjects without known coronary artery disease treated sequentially with three statins of differing potencies. Fractalkine (CX3CL1), GM-CSF, VEGF-A, other chemokines, and lipid

SUBMITTER: Cimato TR 

PROVIDER: S-EPMC4067646 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature