The microRNA bantam regulates a developmental transition in epithelial cells that restricts sensory dendrite growth.

ABSTRACT: As animals grow, many early born structures grow by cell expansion rather than cell addition; thus growth of distinct structures must be coordinated to maintain proportionality. This phenomenon is particularly widespread in the nervous system, with dendrite arbors of many neurons expanding in concert with their substrate to sustain connectivity and maintain receptive field coverage as animals grow. After rapidly growing to establish body wall coverage, dendrites of Drosophila class IV dendrite arborization (C4da) neurons grow synchronously with their substrate, the body wall epithelium, providing a system to study how proportionality is maintained during animal growth. Here, we show that the microRNA bantam (ban) ensures coordinated growth of C4da dendrites and the epithelium through regul

SUBMITTER: Jiang N 

PROVIDER: S-EPMC4067962 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature