Association between preoperative statin use and acute kidney injury biomarkers in cardiac surgical procedures.

ABSTRACT:

Background

Acute kidney injury (AKI) is a serious complication of cardiac operations for which there remains no specific therapy. Animal data and several observational studies suggest that statins prevent AKI, but the results are not conclusive, and many studies are retrospective in nature.

Methods

We conducted a multicenter prospective cohort study of 625 adult patients undergoing elective cardiac operations. All patients were taking statins and were grouped according to whether statins were continued or held in the 24 hours before operation. The primary outcome was AKI as defined by a doubling of serum creatinine or dialysis. The secondary outcome was the peak level of several kidney injury biomarkers. The results were adjusted for demographic and clinical factors.

Resu

SUBMITTER: Molnar AO 

PROVIDER: S-EPMC4068122 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature