Dissociation of innate immune responses in microglia infected with Listeria monocytogenes.

ABSTRACT: Microglia, the innate immune cells of the brain, plays a central role in cerebral listeriosis. Here, we present evidence that microglia control Listeria infection differently than macrophages. Infection of primary microglial cultures and murine cell lines with Listeria resulted in a dual function of the two gene expression programmes involved in early and late immune responses in macrophages. Whereas the bacterial gene hly seems responsible for both transcriptional programmes in macrophages, Listeria induces in microglia only the tumor necrosis factor (TNF)-regulated transcriptional programme. Listeria also represses in microglia the late immune response gathered in two clusters, microbial degradation, and interferon (IFN)-inducible genes. The bacterial gene actA was required in microglia

SUBMITTER: Frande-Cabanes E 

PROVIDER: S-EPMC4068285 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature