Triclosan-induced aminoglycoside-tolerant Listeria monocytogenes isolates can appear as small-colony variants.

ABSTRACT: Exposure of the human food-borne pathogen Listeria monocytogenes to sublethal concentrations of triclosan can cause resistance to several aminoglycosides. Aminoglycoside-resistant isolates exhibit two colony morphologies: normal-size and pinpoint colonies. The purposes of the present study were to characterize the small colonies of L. monocytogenes and to determine if specific genetic changes could explain the triclosan-induced aminoglycoside resistance in both pinpoint and normal-size isolates. Isolates from the pinpoint colonies grew poorly under aerated conditions, but growth was restored by addition of antibiotics. Pinpoint isolates had decreased hemolytic activity under stagnant conditions and a changed spectrum of carbohydrate utilization compared to the wild type and isolates from n

SUBMITTER: Kastbjerg VG 

PROVIDER: S-EPMC4068453 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature