Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules.

ABSTRACT: Therapies to prevent transmission of malaria parasites to the mosquito vector are a vital part of the global malaria elimination agenda. Primaquine is currently the only drug with such activity; however, its use is limited by side effects. The development of transmission-blocking strategies requires an understanding of sexual stage malaria parasite (gametocyte) biology and the identification of new drug leads. Lysine acetylation is an important posttranslational modification involved in regulating eukaryotic gene expression and other essential processes. Interfering with this process with histone deacetylase (HDAC) inhibitors is a validated strategy for cancer and other diseases, including asexual stage malaria parasites. Here we confirm the expression of at least one HDAC protein in Plasm

SUBMITTER: Trenholme K 

PROVIDER: S-EPMC4068603 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature