MicroRNA-26a regulates pathological and physiological angiogenesis by targeting BMP/SMAD1 signaling.

ABSTRACT:

Rationale

The rapid induction and orchestration of new blood vessels are critical for tissue repair in response to injury, such as myocardial infarction, and for physiological angiogenic responses, such as embryonic development and exercise.

Objective

We aimed to identify and characterize microRNAs (miR) that regulate pathological and physiological angiogenesis.

Methods and results

We show that miR-26a regulates pathological and physiological angiogenesis by targeting endothelial cell (EC) bone morphogenic protein/SMAD1 signaling in vitro and in vivo. MiR-26a expression is increased in a model of acute myocardial infarction in mice and in human subjects with acute coronary syndromes. Ectopic expression of miR-26a markedly induced EC cycle arrest and inhibited EC migra

SUBMITTER: Icli B 

PROVIDER: S-EPMC4068743 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature