A diastereodivergent synthetic strategy for the syntheses of communesin F and perophoramidine.

ABSTRACT: An efficient, unified, and stereodivergent approach toward communesin F and perophoramidine was examined. The C(3) all-carbon quaternary center of an oxindole was smoothly constructed by base-promoted indolone-malonate alkylation chemistry. The complementary relative stereochemistry of the crucial vicinal quaternary centers found in communesin F and perophoramidine was selectively installed by substrate-controlled decarboxylative allylic alkylations.

SUBMITTER: Han SJ 

PROVIDER: S-EPMC4068777 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature