Vitamin B12 status in metformin treated patients: systematic review.

ABSTRACT:

Objective

Randomized controlled trials and observational studies have yielded inconsistent results on the effects of metformin on vitamin B12 reduction. We therefore performed a systematic review to analyze the effects of metformin on vitamin B12 concentration.

Methods

PubMed, Medline, Embase, and the Cochrane central registry of controlled trials were searched to identify randomized controlled trials and observational studies exploring the association between metformin and vitamin B12 concentration in patients with type 2 diabetes mellitus or polycystic ovary syndrome. The main outcome measure was changes in serum vitamin B12 concentration after 6-208 weeks of treatment with metformin, as compared with placebo or other anti-hyperglycemic therapy.

Results

Six randomiz

SUBMITTER: Liu Q 

PROVIDER: S-EPMC4069007 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature