Keratinocyte detachment-differentiation connection revisited, or anoikis-pityriasi nexus redux.

ABSTRACT: Epidermis, a continuously self-renewing and differentiating organ, produces a protective stratum corneum that shields us from external chemical, physical and microbial threats. Epidermal differentiation is a multi-step process regulated by influences, some unknown, others insufficiently explored. Detachment of keratinocytes from the basement membrane is one such pro-differentiation stimulus. Here, we define the transcriptional changes during differentiation, especially those caused by detachment from the substratum. Using comprehensive transcriptional profiling, we revisited the effects of detachment as a differentiation signal to keratinocytes. We identified the genes regulated by detachment, the corresponding ontological categories and, using metaanalysis, compared the genes and categori

SUBMITTER: Banno T 

PROVIDER: S-EPMC4069014 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature