Movement dependence and layer specificity of entorhinal phase precession in two-dimensional environments.

ABSTRACT: As a rat moves, grid cells in its entorhinal cortex (EC) discharge at multiple locations of the external world, and the firing fields of each grid cell span a hexagonal lattice. For movements on linear tracks, spikes tend to occur at successively earlier phases of the theta-band filtered local field potential during the traversal of a firing field - a phenomenon termed phase precession. The complex movement patterns observed in two-dimensional (2D) open-field environments may fundamentally alter phase precession. To study this question at the behaviorally relevant single-run level, we analyzed EC spike patterns as a function of the distance traveled by the rat along each trajectory. This analysis revealed that cells across all EC layers fire spikes that phase-precess; indeed, the rate and

SUBMITTER: Reifenstein E 

PROVIDER: S-EPMC4069107 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature