Urinary kidney injury molecule 1 (KIM-1) and interleukin 18 (IL-18) as risk markers for heart failure in older adults: the Health, Aging, and Body Composition (Health ABC) Study.

ABSTRACT:

Background

Kidney damage and reduced kidney function are potent risk factors for heart failure, but existing studies are limited to assessing albuminuria or estimated glomerular filtration rate (eGFR). We evaluated the associations of levels of urinary biomarkers of kidney tubular injury (interleukin 18 [IL-18] and kidney injury molecule 1 [KIM-1]) with future risk of heart failure.

Study design

Retrospective cohort study.

Setting & participants

2,917 participants without heart failure in the Health, Aging, and Body Composition (Health ABC) cohort.

Predictors

Ratios of urine KIM-1, IL-18, and albumin to creatinine (KIM-1:Cr, IL-18:Cr, and ACR, respectively).

Outcomes

Incident heart failure over a median follow-up of 12 years.

Results

Median values

SUBMITTER: Driver TH 

PROVIDER: S-EPMC4069223 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature