IDE (rs6583817) polymorphism and pulse pressure are independently and interactively associated with level and change in executive function in older adults.

ABSTRACT:

Objective

We report a gene × environment (health) study focusing on concurrent performance and longitudinal change in a latent-variable executive function (EF) phenotype. Specifically, we tested the independent and interactive effects of a recently identified insulin degrading enzyme genetic polymorphism (IDE rs6583817) and pulse pressure (PP; one prominent aging-related vascular health indicator) across up to 9 years of EF data in a sample of older adults from the Victoria Longitudinal Study. Both factors vary across a continuum of risk-elevating to risk-reducing and have been recently linked to normal and impaired cognitive aging.

Method

We assembled a genotyped and typically aging group of older adults (n = 599, M age = 66 years at baseline), following them for up to 3 lo

SUBMITTER: McFall GP 

PROVIDER: S-EPMC4069225 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature