Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission.

ABSTRACT: Dysregulated immune responses to gut microbes are central to inflammatory bowel disease (IBD), and gut microbial activity can fuel chronic inflammation. Examining how IBD-directed therapies influence gut microbiomes may identify microbial community features integral to mitigating disease and maintaining health. However, IBD patients often receive multiple treatments during disease flares, confounding such analyses. Preclinical models of IBD with well-defined disease courses and opportunities for controlled treatment exposures provide a valuable solution. Here, we surveyed the gut microbiome of the T-bet(-/-) Rag2(-/-) mouse model of colitis during active disease and treatment-induced remission. Microbial features modified among these conditions included altered potential for carbohydrate a

SUBMITTER: Rooks MG 

PROVIDER: S-EPMC4069400 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature