Axonal and dendritic density field estimation from incomplete single-slice neuronal reconstructions.

ABSTRACT: Neuronal information processing in cortical networks critically depends on the organization of synaptic connectivity. Synaptic connections can form when axons and dendrites come in close proximity of each other. The spatial innervation of neuronal arborizations can be described by their axonal and dendritic density fields. Recently we showed that potential locations of synapses between neurons can be estimated from their overlapping axonal and dendritic density fields. However, deriving density fields from single-slice neuronal reconstructions is hampered by incompleteness because of cut branches. Here, we describe a method for recovering the lost axonal and dendritic mass. This so-called completion method is based on an estimation of the mass inside the slice and an extrapolation to the s

SUBMITTER: van Pelt J 

PROVIDER: S-EPMC4069480 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature