A cross talk between codon usage bias in human oncogenes.

ABSTRACT:

Background

Oncogenes are the genes that have the potential to induce cancer. The extent and origin of codon usage bias is an important indicator of the forces shaping genome evolution in living organisms.

Results

We observed moderate correlations between gene expression as measured by CAI and GC content at any codon site. The findings of our results showed that there is a significant positive correlation (Spearman's r= 0.45, P<0.01) between GC content at first and second codon position with that of third codon position. Further, striking negative correlation (r = -0.771, P < 0.01) between ENC with the GC3s values of each gene and positive correlation (r=0.644, P<0.01) in between CAI and ENC was also observed.

Conclusions

The mutation pressure is the major determining

SUBMITTER: Mazumder TH 

PROVIDER: S-EPMC4070033 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature