Effect of vitamin D-binding protein genotype on the development of asthma in children.

ABSTRACT:

Background

Potential vitamin D-related influences on inflammatory diseases such as asthma are controversial, including the suggestion that vitamin D insufficiency is associated with increased asthma morbidity. Vitamin D-binding protein transports vitamin D metabolites in the circulation. Single nucleotide polymorphisms in the GC gene encoding vitamin D-binding protein are associated with circulating vitamin D metabolite levels in healthy infants and toddlers.

Objective

To test the hypothesis that GC single nucleotide polymorphisms encoding the D432E and T436K variants predict subsequent development of asthma in healthy children.

Methods

A retrospective medical record review was performed to determine the development of asthma in 776 children in whom GC genotype, vitam

SUBMITTER: Navas-Nazario A 

PROVIDER: S-EPMC4070170 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature