The VGF-derived peptide TLQP-21 contributes to inflammatory and nerve injury-induced hypersensitivity.

ABSTRACT: VGF (nonacronymic) is a granin-like protein that is packaged and proteolytically processed within the regulated secretory pathway. VGF and peptides derived from its processing have been implicated in neuroplasticity associated with learning, memory, depression, and chronic pain. In sensory neurons, VGF is rapidly increased following peripheral nerve injury and inflammation. Several bioactive peptides generated from the C-terminus of VGF have pronociceptive spinal effects. The goal of the present study was to examine the spinal effects of the peptide TLQP-21 and determine whether it participates in spinal mechanisms of persistent pain. Application of exogenous TLQP-21 induced dose-dependent thermal hyperalgesia in the warm-water immersion tail-withdrawal test. This hyperalgesia was inhibite

SUBMITTER: Fairbanks CA 

PROVIDER: S-EPMC4070220 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature