Silencing BMP-2 expression inhibits A549 and H460 cell proliferation and migration.

ABSTRACT:

Background

Bone morphogenetic protein 2 (BMP-2) is a member of the TGF-β superfamily that is closely correlated with many malignancies, particularly lung cancer. However, the effects of silenced BMP-2 on lung cancer cell proliferation and migration are not clear.

Methods

Using quantitative real-time RT-PCR, BMP-2 mRNA expression was detected in 61 non-small cell lung cancer (NSCLC) samples. Survival curves were generated using follow-up data. Relationships between clinical or pathological characteristics and prognosis were analyzed. Cell viability assays and transwell migration assays were used to evaluate the effects of BMP-2 silencing on cell proliferation and migration of A549 and H460 cells.

Results

BMP-2 mRNA expression was higher in NSCLC tissues compared to mat

SUBMITTER: Chu H 

PROVIDER: S-EPMC4070338 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature