Structure of the gut microbiome following colonization with human feces determines colonic tumor burden.

ABSTRACT:

Background

A growing body of evidence indicates that the gut microbiome plays a role in the development of colorectal cancer (CRC). Patients with CRC harbor gut microbiomes that are structurally distinct from those of healthy individuals; however, without the ability to track individuals during disease progression, it has not been possible to observe changes in the microbiome over the course of tumorigenesis. Mouse models have demonstrated that these changes can further promote colonic tumorigenesis. However, these models have relied upon mouse-adapted bacterial populations and so it remains unclear which human-adapted bacterial populations are responsible for modulating tumorigenesis.

Results

We transplanted fecal microbiota from three CRC patients and three healthy individ

SUBMITTER: Baxter NT 

PROVIDER: S-EPMC4070349 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature