Heterologous expression and manipulation of three tetracycline biosynthetic pathways.

ABSTRACT: A very accommodating host: Three tetracycline biosynthetic pathways were overexpressed and manipulated in the heterologous host Streptomyces lividans K4-114. Through the inactivation of various genes and characterization of the resulting biosynthetic intermediates, new tetracycline-modifying enzymes were identified (see scheme).

SUBMITTER: Wang P 

PROVIDER: S-EPMC4070387 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature