Ethanol Extract of Alismatis rhizome Inhibits Adipocyte Differentiation of OP9 Cells.

ABSTRACT: The rhizome of Alisma orientale (Alismatis rhizome) has been used in Asia for promoting diuresis to eliminate dampness from the lower-jiao and to expel heat. In this study, an ethanol extract of the rhizome of Alisma orientale (AOE) was prepared and its effects on adipocyte differentiation of OP9 cells were investigated. Treatment with AOE in a differentiation medium for 5 days resulted in dose-dependent inhibition of lipid droplet formation in OP9 cells. Furthermore, AOE significantly inhibited adipocyte differentiation by downregulating the expression of the master transcription factor of adipogenesis, peroxisome proliferation-activity receptor γ (PPAR γ ), and related genes, including CCAAT/enhancer binding protein β (C/EBP β ), fatty acid-binding protein (aP2), and fatty acid synthase

SUBMITTER: Park YJ 

PROVIDER: S-EPMC4070469 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature