Genetic Variants in the FADS Gene: Implications for Dietary Recommendations for Fatty Acid Intake.

ABSTRACT: Unequivocally, genetic variants within the fatty acid desaturase (FADS) cluster are determinants of long chain polyunsaturated fatty acid (LC-PUFA) levels in circulation, cells and tissues. A recent series of papers have addressed these associations in the context of ancestry; evidence clearly supports that the associations are robust to ethnicity. However ∼80% of African Americans carry two copies of the alleles associated with increased levels of arachidonic acid, compared to only ∼45% of European Americans raising important questions of whether gene-PUFA interactions induced by a modern western diet are differentially driving the risk of diseases of inflammation in diverse populations, and are these interactions leading to health disparities. We highlight an important aspect thus

SUBMITTER: Mathias RA 

PROVIDER: S-EPMC4070521 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature