Gene co-expression network analysis identifies porcine genes associated with variation in Salmonella shedding.

ABSTRACT:

Background

Salmonella enterica serovar Typhimurium is a gram-negative bacterium that can colonise the gut of humans and several species of food producing farm animals to cause enteric or septicaemic salmonellosis. While many studies have looked into the host genetic response to Salmonella infection, relatively few have used correlation of shedding traits with gene expression patterns to identify genes whose variable expression among different individuals may be associated with differences in Salmonella clearance and resistance. Here, we aimed to identify porcine genes and gene co-expression networks that differentiate distinct responses to Salmonella challenge with respect to faecal Salmonella shedding.

Results

Peripheral blood transcriptome profiles from 16 pigs belonging t

SUBMITTER: Kommadath A 

PROVIDER: S-EPMC4070558 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature