Expression-based network biology identifies immune-related functional modules involved in plant defense.

ABSTRACT:

Background

Plants respond to diverse environmental cues including microbial perturbations by coordinated regulation of thousands of genes. These intricate transcriptional regulatory interactions depend on the recognition of specific promoter sequences by regulatory transcription factors. The combinatorial and cooperative action of multiple transcription factors defines a regulatory network that enables plant cells to respond to distinct biological signals. The identification of immune-related modules in large-scale transcriptional regulatory networks can reveal the mechanisms by which exposure to a pathogen elicits a precise phenotypic immune response.

Results

We have generated a large-scale immune co-expression network using a comprehensive set of Arabidopsis thaliana (here

SUBMITTER: Tully JP 

PROVIDER: S-EPMC4070563 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature