Early change in proteinuria as a surrogate end point for kidney disease progression: an individual patient meta-analysis.

ABSTRACT:

Background

It is controversial whether proteinuria is a valid surrogate end point for randomized trials in chronic kidney disease.

Study design

Meta-analysis of individual patient-level data.

Setting & population

Individual patient data for 9,008 patients from 32 randomized trials evaluating 5 intervention types.

Selection criteria for studies

Randomized controlled trials of kidney disease progression until 2007 with measurements of proteinuria both at baseline and during the first year of follow-up, with at least 1 further year of follow-up for the clinical outcome.

Predictor

Early change in proteinuria.

Outcomes

Doubling of serum creatinine level, end-stage renal disease, or death.

Results

Early decline in proteinuria was associated with

SUBMITTER: Inker LA 

PROVIDER: S-EPMC4070618 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature