Everolimus in patients with severe pulmonary hypertension: a safety and efficacy pilot trial.

ABSTRACT: Abstract Despite the availability of vasodilating compounds, pulmonary hypertension (PH) of various origins remains a disease with a poor prognosis. In recent years, pulmonary arterial hypertension (PAH) has been recognized as a predominantly proliferative process. Everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), inhibits cellular protein synthesis and growth not only in lymphocytes but also in cells of the vascular wall. Ten patients suffering from PAH ([Formula: see text]) or chronic thromboembolic PH ([Formula: see text]) with progressive disease despite therapy with at least 2 vasodilating drugs were included in a prospective open-label pilot study. All patients were treated with everolimus in addition to their prior medication. Safety and tolerability were observe

SUBMITTER: Seyfarth HJ 

PROVIDER: S-EPMC4070806 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature