Association between RANTES gene polymorphisms and asthma: a meta-analysis.

ABSTRACT:

Background

A few recent studies have suggested that regulated on activation, normal T cell expressed and secreted (RANTES) polymorphisms (-403 G/A, -28C/G) are associated with asthma. However, there still existed studies which did not confirm these correlations.

Objective

The objective of this study was to evaluate the relationship of RANTES and asthma using a meta-analysis.

Methods

Pubmed, Embase, and Cochrane library databases were systemically searched. Data were extracted by two independent reviewers and pooled odds ratio (OR) with 95% confidence interval (CI) were calculated.

Results

Eighteen studies were enrolled, including a total of 2558 cases and 2630 controls of -403 G/A, as well as 3311 cases and 4031 controls of -28C/G in this meta-analysis. The ove

SUBMITTER: Wen D 

PROVIDER: S-EPMC4070887 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature