Plasmodium vivax sporozoite challenge in malaria-naive and semi-immune Colombian volunteers.

ABSTRACT:

Background

Significant progress has been recently achieved in the development of Plasmodium vivax challenge infections in humans, which are essential for vaccine and drug testing. With the goal of accelerating clinical development of malaria vaccines, the outcome of infections experimentally induced in naïve and semi-immune volunteers by infected mosquito bites was compared.

Methods

Seven malaria-naïve and nine semi-immune Colombian adults (n = 16) were subjected to the bites of 2-4 P. vivax sporozoite-infected Anopheles mosquitoes. Parasitemia levels, malaria clinical manifestations, and immune responses were assessed and compared.

Results

All volunteers developed infections as confirmed by microscopy and RT-qPCR. No significant difference in the pre-patent period (m

SUBMITTER: Arevalo-Herrera M 

PROVIDER: S-EPMC4070897 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature