Age at menarche and risks of all-cause and cardiovascular death: a systematic review and meta-analysis.

ABSTRACT: We conducted a systematic review and meta-analysis to investigate the associations between menarcheal age and all-cause and cardiovascular death. Medline, Embase, Scopus, and Web of Knowledge were searched for articles published prior to March 2013 reporting on the associations between menarcheal age and death from all causes or from cardiovascular disease (total cardiovascular disease, ischemic heart disease (IHD), and stroke) in adult women. Nine articles were eligible for inclusion; these reported 5 estimates each for death from all causes and total cardiovascular death, 6 estimates for IHD, and 7 estimates for death from stroke. Our meta-analysis showed that each 1-year increase in age at menarche was associated with a 3% lower relative risk of death from all causes (pooled hazard rati

SUBMITTER: Charalampopoulos D 

PROVIDER: S-EPMC4070937 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature