Smoking is a risk factor for the progression of idiopathic membranous nephropathy.

ABSTRACT:

Background

Multiple studies have shown cigarette smoking to be a risk factor for chronic kidney disease. However, it is unknown whether smoking similarly increases the risk for progression of membranous nephropathy.

Methods

This study used the Nagoya Nephrotic Syndrome Cohort Study (N-NSCS), including 171 patients with idiopathic membranous nephropathy (IMN) from 10 nephrology centers in Japan. The dose-response relationships between cigarette smoking and the outcomes were assessed by using multivariate Cox proportional hazards models adjusted for clinically relevant factors. The primary outcome was a 30% decline in the estimated glomerular filtration rate (eGFR). The secondary outcome was first complete remission (CR) of proteinuria.

Results

During the observation pe

SUBMITTER: Yamaguchi M 

PROVIDER: S-EPMC4071015 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature