The impact of endothelial progenitor cells on restenosis after percutaneous angioplasty of hemodialysis vascular access.

ABSTRACT:

Objective

We prospectively investigate the relation between baseline circulating endothelial progenitor cells and the subsequent development of restenosis after angioplasty of hemodialysis vascular access.

Background

Effect of angioplasty for hemodialysis vascular access is greatly attenuated by early and frequent restenosis. Circulating endothelial progenitor cells (EPCs) play a key role in vascular repair but are deficient in hemodialysis patients.

Method

After excluding 14 patients due to arterial stenosis, central vein stenosis, and failed angioplasty, 130 patients undergoing angioplasty for dysfunctional vascular access were prospectively enrolled. Flow cytometry with quantification of EPC markers (defined as CD34+, CD34+KDR+, CD34+KDR+CD133+) in peripheral blood

SUBMITTER: Wu CC 

PROVIDER: S-EPMC4071067 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature