Irritable bowel syndrome may be associated with maternal inheritance and mitochondrial DNA control region sequence variants.

ABSTRACT:

Background and aim

Mitochondrial dysfunction has been implicated in various functional disorders that are co-morbid to irritable bowel syndrome (IBS) such as migraine, depression and chronic fatigue syndrome. The aim of the current case-control pilot study was to determine if functional symptoms in IBS show a maternal inheritance bias, and if the degree of this maternal inheritance is related to mitochondrial DNA (mtDNA) polymorphisms.

Methods

Pedigrees were obtained from 308 adult IBS patients, 102 healthy controls, and 36 controls with inflammatory bowel disease (IBD), all from Caucasian heritage, to determine probable maternal inheritance. Two mtDNA polymorphisms (16519T and 3010A), which have previously been implicated in other functional disorders, were assayed in mtDNA

SUBMITTER: van Tilburg MA 

PROVIDER: S-EPMC4071137 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature