Is more better? Using metadata to explore dose-response relationships in stroke rehabilitation.

ABSTRACT:

Background and purpose

Neurophysiological models of rehabilitation and recovery suggest that a large volume of specific practice is required to induce the neuroplastic changes that underlie behavioral recovery. The primary objective of this meta-analysis was to explore the relationship between time scheduled for therapy and improvement in motor therapy for adults after stroke by (1) comparing high doses to low doses and (2) using metaregression to quantify the dose-response relationship further.

Methods

Databases were searched to find randomized controlled trials that were not dosage matched for total time scheduled for therapy. Regression models were used to predict improvement during therapy as a function of total time scheduled for therapy and years after stroke.

Resul

SUBMITTER: Lohse KR 

PROVIDER: S-EPMC4071164 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature