Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects.

ABSTRACT:

Background

Schizophrenia is associated with immune system dysfunction, including aberrant cytokine levels. We performed a meta-analysis of these associations, considering effects of clinical status and antipsychotic treatment following an acute illness exacerbation.

Methods

We identified articles by searching PubMed, PsychInfo, and Institute for Scientific Information and the reference lists of identified studies.

Results

Forty studies met the inclusion criteria. Effect sizes were similar for studies of acutely relapsed inpatients (AR) and first-episode psychosis (FEP). Interleukin (IL)-1β, IL-6, and transforming growth factor-β (TGF-β) appeared to be state markers, as they were increased in AR and FEP (p < .001 for each) and normalized with antipsychotic treatment (p

SUBMITTER: Miller BJ 

PROVIDER: S-EPMC4071300 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature