Network-dosage compensation topologies as recurrent network motifs in natural gene networks.

ABSTRACT:

Background

Global noise in gene expression and chromosome duplication during cell-cycle progression cause inevitable fluctuations in the effective number of copies of gene networks in cells. These indirect and direct alterations of network copy numbers have the potential to change the output or activity of a gene network. For networks whose specific activity levels are crucial for optimally maintaining cellular functions, cells need to implement mechanisms to robustly compensate the effects of network dosage fluctuations.

Results

Here, we determine the necessary conditions for generalized N-component gene networks to be network-dosage compensated and show that the compensation mechanism can robustly operate over large ranges of gene expression levels. Furthermore, we show th

SUBMITTER: Song R 

PROVIDER: S-EPMC4071340 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature